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Cruises from USA to Panama

Are you looking for a cruise from USA to Panama? December and November are the most popular months to cruise between USA and Panama and there are 26 departures available from eight of the world's leading cruise lines.
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22 Cruises (26 Cruise Departures)
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 08 February 2025
Countries Visited: USA, Mexico, Belize, Guatemala (+3 more), Honduras, Costa Rica, Panama
Bonus SavingsExclusive Deal
INSIDE
$4,075
OCEANVIEW
$4,487
BALCONY
-
SUITE
-
Save (per person) 3,045
From (per person) 4,075
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (6)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Oct 2025 to Dec 2025
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$6,365
SUITE
$9,305
Save (per person) 143
From (per person) 6,365
View Trip
11 Day CEO Loyalty Panama Canal Voyage with Azamara Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 03 December 2024
Countries Visited: USA, Aruba, Bonaire, Curacao (+2 more), Colombia, Panama
Circle Club Voyage
INSIDE
$2,419
OCEANVIEW
$2,479
BALCONY
-
SUITE
-
From (per person) 2,419
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Fort Lauderdale to Santiago
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2024 to Oct 2025
Countries Visited: USA, Mexico, Panama, Ecuador (+2 more), Peru, Chile
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$10,885
SUITE
$15,340
Save (per person) 5,312
From (per person) 10,885
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 23 March 2025
Countries Visited: USA, Bahamas, Mexico, Guatemala (+4 more), Belize, Honduras, Costa Rica, Panama
Bonus SavingsExclusive Deal
INSIDE
$3,599
OCEANVIEW
$3,874
BALCONY
$5,604
SUITE
$7,505
Save (per person) 3,221
From (per person) 3,599
View Trip
19 Day Andes & South America with Princess
Cruise
 (3)

19 Days (18 Nights) Los Angeles to Santiago
Cruise Line: Princess
Ship: Majestic Princess
Departure: 01 December 2024
Countries Visited: USA, Mexico, Panama, Peru (+1 more), Chile
Exclusive Deal
INSIDE
$2,128
OCEANVIEW
-
BALCONY
$2,435
SUITE
$2,900
From (per person) 2,128
View Trip
11 Day Panama Canal - Tampa with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 16 January 2026
Countries Visited: USA, Mexico, Belize, Honduras (+3 more), Cayman Islands, Colombia, Panama
More At Sea Offer
INSIDE
$3,535
OCEANVIEW
$3,995
BALCONY
$5,217
SUITE
$5,646
From (per person) 3,535
View Trip
11 Day Vivid Western Caribbean with Oceania Cruises
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 April 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$4,484
OCEANVIEW
$4,939
BALCONY
$7,315
SUITE
$10,147
Save (per person) 2,026
From (per person) 4,484
View Trip
11 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 12 December 2025
Countries Visited: USA, Mexico, Belize, Honduras (+3 more), Cayman Islands, Colombia, Panama
More At Sea OfferExclusive Solo Offer
INSIDE
$3,605
OCEANVIEW
$4,065
BALCONY
$5,287
SUITE
$5,671
From (per person) 3,605
View Trip
15 Day Exotic Coasts & Casco Viejo with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 23 February 2027
Countries Visited: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,033
SUITE
$13,993
Save (per person) 7,357
From (per person) 13,033
View Trip
8 Day Fort Lauderdale to Panama City with Silversea
Cruise

8 Days (7 Nights) Fort Lauderdale to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 17 December 2024
Countries Visited: USA, Colombia, Panama
Port-to-Port
INSIDE
-
OCEANVIEW
-
BALCONY
$7,029
SUITE
$15,840
From (per person) 7,029
View Trip
13 Day Majestic Beaches & Canal Crossing with Regent Seven Seas
Cruise

13 Days (12 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 03 January 2026
Countries Visited: USA, Cayman Islands, Jamaica, Bonaire (+5 more), Curacao, Aruba, Colombia, Costa Rica, Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,581
SUITE
$13,175
Save (per person) 6,309
From (per person) 12,581
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Los Angeles to Colon
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 02 November 2025
Countries Visited: USA, Mexico, Guatemala, Nicaragua (+2 more), Costa Rica, Panama
Bonus SavingsExclusive Deal
INSIDE
$4,983
OCEANVIEW
$5,579
BALCONY
$8,128
SUITE
$11,416
Save (per person) 2,587
From (per person) 4,983
View Trip
10 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Miami to Panama City
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 01 November 2025
Countries Visited: USA, Dominican Republic, Aruba, Colombia (+1 more), Panama
More At Sea Offer
INSIDE
$3,201
OCEANVIEW
$3,660
BALCONY
$4,807
SUITE
$5,112
From (per person) 3,201
View Trip
11 Day Palms & Panama Canal with Oceania Cruises
Cruise

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$4,642
OCEANVIEW
$5,088
BALCONY
$7,464
SUITE
$10,295
Save (per person) 2,028
From (per person) 4,642
View Trip
11 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Galveston to Panama City
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 06 February 2026
Countries Visited: USA, Mexico, Belize, Honduras (+3 more), Cayman Islands, Colombia, Panama
More At Sea Offer
INSIDE
$3,608
OCEANVIEW
$4,022
BALCONY
$5,321
SUITE
$5,749
From (per person) 3,608
View Trip
21 Day Andes & South America with Princess
Cruise

21 Days (20 Nights) Los Angeles to Santiago
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 16 November 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+3 more), Ecuador, Peru, Chile
Exclusive Deal
INSIDE
$2,943
OCEANVIEW
$2,986
BALCONY
$3,418
SUITE
$4,804
From (per person) 2,943
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Countries Visited: USA, Bahamas, Colombia, Panama
Exclusive DealEarlybird Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$19,939
SUITE
$25,126
Save (per person) 7,201
From (per person) 19,939
View Trip
12 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Tampa to Panama City
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 29 January 2025
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+3 more), Colombia, Panama, Costa Rica
More At Sea Offer
INSIDE
$2,208
OCEANVIEW
$2,514
BALCONY
$3,738
SUITE
$4,272
From (per person) 2,208
View Trip
10 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Miami to Panama City
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 02 December 2024
Countries Visited: USA, Dominican Republic, Curacao, Aruba (+1 more), Panama
More At Sea Offer
INSIDE
$1,637
OCEANVIEW
$1,713
BALCONY
$1,790
SUITE
$2,142
From (per person) 1,637
View Trip
23 Day Palms To Andean Peaks with Oceania Cruises
Cruise

23 Days (22 Nights) Miami to Santiago
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 29 November 2025
Countries Visited: USA, Mexico, Belize, Guatemala (+6 more), Honduras, Costa Rica, Panama, Ecuador, Peru, Chile
Bonus SavingsExclusive Deal
INSIDE
$7,535
OCEANVIEW
$9,415
BALCONY
$10,752
SUITE
$15,982
Save (per person) 2,885
From (per person) 7,535
View Trip
12 Day San Diego to Panama City with Silversea
Cruise

12 Days (11 Nights) San Diego to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama
Port-to-Port
INSIDE
-
OCEANVIEW
$8,019
BALCONY
$9,207
SUITE
-
From (per person) 8,019
View Trip
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Travel Styles

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Countries

Bahamas Bermuda Canada Mexico USA

Cities

Fort Lauderdale Galveston Los Angeles Miami New York San Diego Tampa

Routes

Cruises from Baltimore to Baltimore Cruises from Boston to Boston Cruises from Cape Liberty to Cape Liberty Cruises from Fort Lauderdale to Los Angeles Cruises from Fort Lauderdale to Fort Lauderdale Cruises from Fort Lauderdale to San Diego Cruises from Galveston to Galveston Cruises from Los Angeles to Miami Cruises from Los Angeles to Los Angeles Cruises from Miami to Los Angeles Cruises from Miami to Miami Cruises from New Orleans to New Orleans Cruises from New York to New York Cruises from Orlando to Orlando Cruises from San Diego to Fort Lauderdale Cruises from San Diego to San Diego Cruises from San Francisco to San Francisco Cruises from Seattle to Seattle Cruises from Tampa to Tampa

Country Routes

Cruises from USA to Panama Cruises from USA to Peru

Cruise Lines

Abercrombie & Kent APT Azamara Celebrity Cruises Celestyal Cruises Cunard Emerald Cruises Explora Journeys G Adventures Heritage Expeditions Holland America Hurtigruten HX Hurtigruten Intrepid MSC Cruises Norwegian Cruise Line Oceania P&O Cruises P&O Cruises Worldwide Ponant Princess Regent Seven Seas Royal Caribbean Scenic Seabourn Silversea Tauck Travelmarvel Viking Virgin Voyages Wendy Wu

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