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Panama Cruises

Are you looking for a cruise to Panama? Choose from 73 unique cruise itineraries to Panama, departing from Cartagena, Colon, Fort Lauderdale, Lima, London and more. January is the most popular month to cruise to Panama and we have over 120 departures available from thirteen of the world's leading cruise lines.
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27 Days
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73 Cruises (120 Cruise Departures)
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Bellot
Departures: Feb 2025 to Feb 2025
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$11,912
SUITE
$21,565
Save (per person) 268
From (per person) 11,912
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 26 February 2026
Countries Visited: Costa Rica, Panama
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,203
SUITE
$13,809
Save (per person) 157
From (per person) 8,203
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,174
SUITE
$13,779
Save (per person) 156
From (per person) 8,174
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America - with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Bellot
Departure: 06 January 2025
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$10,771
SUITE
$15,739
Save (per person) 209
From (per person) 10,771
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Bellot
Departures: Feb 2025 to Mar 2025
Countries Visited: Costa Rica, Panama
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$13,892
SUITE
$29,258
Save (per person) 644
From (per person) 13,892
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Countries Visited: Panama, Colombia
Exclusive DealExclusive Solo Offer
INSIDE
$207
OCEANVIEW
$275
BALCONY
$326
SUITE
$475
Save (per person) 177
From (per person) 207
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 15 March 2026
Countries Visited: Costa Rica, Panama
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$9,932
SUITE
$16,998
Save (per person) 188
From (per person) 9,932
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Countries Visited: Panama, Chile
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,311
SUITE
$10,746
Save (per person) 3,084
From (per person) 8,311
View Trip
12 Day The Panama Canal & Costa Rica - Westbound with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 18 January 2025
Countries Visited: Panama, Costa Rica
From (per person) 14,250
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$10,540
SUITE
$18,086
Save (per person) 200
From (per person) 10,540
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) San Jose to Panama City
Operated By: Tauck
Departure: 25 January 2025
Countries Visited: Costa Rica, Panama
From (per person) 13,640
View Trip
14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (1)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Countries Visited: Chile, Peru, Panama
INSIDE
$6,252
OCEANVIEW
$7,598
BALCONY
$8,984
SUITE
$10,519
From (per person) 6,252
View Trip
8 Day Lima to Panama City with Silversea
Cruise

8 Days (7 Nights) Lima to Panama City
Cruise Line: Silversea
Ship: Silver Ray
Departure: 04 January 2025
Countries Visited: Peru, Ecuador, Panama
Essential FarePort-to-Port
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$4,851
From (per person) 4,851
View Trip
8 Day Fort Lauderdale to Panama City with Silversea
Cruise

8 Days (7 Nights) Fort Lauderdale to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 17 December 2024
Countries Visited: USA, Colombia, Panama
Port-to-Port
INSIDE
-
OCEANVIEW
-
BALCONY
$7,029
SUITE
$15,840
From (per person) 7,029
View Trip
11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Countries Visited: Bahamas, Colombia, Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,440
SUITE
$12,816
Save (per person) 3,605
From (per person) 10,440
View Trip
20 Day Treasures of French Polynesia & the Marquesas Islands with Scenic
New ReleaseCruise

20 Days (19 Nights) Papeete to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 25 March 2026
Countries Visited: French Polynesia, Costa Rica, Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,509
SUITE
$18,815
Save (per person) 6,636
From (per person) 13,509
View Trip
8 Day Natural Sanctuaries & Heritage of the Caribbean with Ponant
Cruise

8 Days (7 Nights) Willemstad to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 26 November 2025
Countries Visited: Curacao, Colombia, Panama
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$6,126
SUITE
$9,810
Save (per person) 114
From (per person) 6,126
View Trip
20 Day New York To San Francisco with Cunard
Cruise
 (3)

20 Days (19 Nights) New York to San Francisco
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 18 January 2026
Countries Visited: USA, Curacao, Panama, Mexico
Exclusive Deal
INSIDE
$4,203
OCEANVIEW
$6,342
BALCONY
$6,579
SUITE
-
From (per person) 4,203
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Nov 2025
Countries Visited: Colombia, Bonaire, Curacao, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,552
OCEANVIEW
$1,600
BALCONY
$1,729
SUITE
$2,236
Save (per person) 818
From (per person) 1,552
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Nov 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive DealExclusive Solo Offer
INSIDE
$1,343
OCEANVIEW
$1,404
BALCONY
$1,559
SUITE
$2,094
Save (per person) 756
From (per person) 1,343
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Dec 2025 to Feb 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive DealExclusive Solo Offer
INSIDE
$1,084
OCEANVIEW
$1,235
BALCONY
$1,520
SUITE
$2,368
Save (per person) 940
From (per person) 1,084
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Dec 2025 to Feb 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive DealExclusive Solo Offer
INSIDE
$1,159
OCEANVIEW
$1,303
BALCONY
$1,588
SUITE
$2,444
Save (per person) 807
From (per person) 1,159
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 06 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive DealExclusive Solo Offer
INSIDE
$1,325
OCEANVIEW
$1,441
BALCONY
$1,638
SUITE
$2,371
Save (per person) 695
From (per person) 1,325
View Trip
12 Day Panama City to Los Angeles with Silversea
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 24 December 2024
Countries Visited: Panama, Costa Rica, Mexico, USA
Port-to-Port
INSIDE
-
OCEANVIEW
$7,623
BALCONY
$10,791
SUITE
$22,572
From (per person) 7,623
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Countries Visited: Colombia, Aruba, Curacao, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,413
OCEANVIEW
$1,454
BALCONY
$1,220
SUITE
$2,588
Save (per person) 732
From (per person) 1,220
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive DealExclusive Solo Offer
INSIDE
$1,325
OCEANVIEW
$1,419
BALCONY
$1,363
SUITE
$2,095
Save (per person) 749
From (per person) 1,325
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive DealExclusive Solo Offer
INSIDE
$1,740
OCEANVIEW
$1,890
BALCONY
$2,175
SUITE
$3,025
Save (per person) 885
From (per person) 1,740
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 07 December 2025
Countries Visited: Colombia, Aruba, Curacao, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,560
OCEANVIEW
$1,601
BALCONY
$1,805
SUITE
$2,531
Save (per person) 805
From (per person) 1,560
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 17 January 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive DealExclusive Solo Offer
INSIDE
$1,132
OCEANVIEW
$1,275
BALCONY
$1,560
SUITE
$2,416
Save (per person) 603
From (per person) 1,132
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Nov 2025
Countries Visited: Colombia, Aruba, Curacao, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,560
OCEANVIEW
$1,636
BALCONY
$1,702
SUITE
$2,168
Save (per person) 859
From (per person) 1,560
View Trip
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