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Cruises from Panama to USA

Are you looking for a cruise from Panama to USA? February is the most popular month to cruise between Panama and USA and there are 24 departures available from seven of the world's leading cruise lines.
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20 Cruises (24 Cruise Departures)
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (6)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Dec 2024 to Dec 2025
Countries Visited: Panama, Costa Rica, Honduras, Belize (+2 more), Mexico, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$6,430
SUITE
$9,795
Save (per person) 1,065
From (per person) 6,430
View Trip
12 Day Caribbean Quest Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 15 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire (+3 more), Curacao, Dominican Republic, USA
INSIDE
$4,853
OCEANVIEW
$6,070
BALCONY
$7,179
SUITE
$9,030
From (per person) 4,853
View Trip
11 Day Captivating Panama Canal with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 April 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Bonaire, Jamaica, USA
Bonus SavingsExclusive Deal
INSIDE
$4,314
OCEANVIEW
$4,778
BALCONY
$6,854
SUITE
$9,135
Save (per person) 2,506
From (per person) 4,314
View Trip
10 Day Panama Canal Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 13 December 2024
Countries Visited: Panama, Costa Rica, Honduras, Guatemala (+2 more), Mexico, USA
Circle Club Voyage
INSIDE
$1,923
OCEANVIEW
$2,012
BALCONY
$2,468
SUITE
-
From (per person) 1,923
View Trip
12 Day Classic Panama Canal with Oceania Cruises
Cruise
 (2)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 February 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Bonaire, Jamaica, Bahamas, USA
Bonus SavingsExclusive Deal
INSIDE
$4,984
OCEANVIEW
$5,385
BALCONY
-
SUITE
$10,874
Save (per person) 2,586
From (per person) 4,984
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2025 to Mar 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Mexico, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$15,835
SUITE
$24,495
Save (per person) 1,160
From (per person) 15,835
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 04 April 2026
Countries Visited: Panama, Colombia, Curacao, Aruba (+3 more), Jamaica, Cayman Islands, USA
Exclusive Deal
INSIDE
$4,641
OCEANVIEW
$5,086
BALCONY
$7,462
SUITE
$10,293
Save (per person) 2,029
From (per person) 4,641
View Trip
12 Day Panama City to Los Angeles with Silversea
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 24 December 2024
Countries Visited: Panama, Costa Rica, Mexico, USA
Port-to-Port
INSIDE
-
OCEANVIEW
$7,623
BALCONY
$10,791
SUITE
$22,572
From (per person) 7,623
View Trip
14 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

14 Days (13 Nights) Panama City to New York
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 22 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+5 more), Saint Lucia, Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
More At Sea Offer
INSIDE
$5,014
OCEANVIEW
$5,779
BALCONY
$7,691
SUITE
$8,838
From (per person) 5,014
View Trip
18 Day San Antonio To Fort Lauderdale with Cunard
Cruise

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+3 more), Aruba, Bahamas, USA
Exclusive Deal
INSIDE
$5,252
OCEANVIEW
$6,192
BALCONY
$8,321
SUITE
$18,439
From (per person) 5,252
View Trip
12 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Panama City to Galveston
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 26 January 2026
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
More At Sea Offer
INSIDE
$3,824
OCEANVIEW
$4,359
BALCONY
$5,736
SUITE
$6,241
From (per person) 3,824
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,064
SUITE
$10,658
Save (per person) 6,286
From (per person) 10,064
View Trip
11 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 10 November 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
More At Sea OfferExclusive Solo Offer
INSIDE
$3,609
OCEANVIEW
$4,069
BALCONY
$5,291
SUITE
$5,675
From (per person) 3,609
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Colon to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 14 November 2025
Countries Visited: Panama, Costa Rica, Nicaragua, Guatemala (+2 more), Mexico, USA
Bonus SavingsExclusive Deal
INSIDE
$4,981
OCEANVIEW
$5,578
BALCONY
$8,127
SUITE
$11,414
Save (per person) 2,589
From (per person) 4,981
View Trip
32 Day San Antonio To Southampton with Cunard
Cruise

32 Days (31 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+6 more), Aruba, Bahamas, USA, Bermuda, Portugal, England
Exclusive Deal
INSIDE
$5,791
OCEANVIEW
$6,966
BALCONY
$9,103
SUITE
$24,275
From (per person) 5,791
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$4,483
OCEANVIEW
$4,938
BALCONY
$7,314
SUITE
$10,145
Save (per person) 2,027
From (per person) 4,483
View Trip
11 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Panama City to Tampa
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 19 January 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
More At Sea Offer
INSIDE
$2,230
OCEANVIEW
$2,306
BALCONY
$4,064
SUITE
$4,187
From (per person) 2,230
View Trip
10 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Panama City to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 11 December 2024
Countries Visited: Panama, Costa Rica, Jamaica, Cayman Islands (+3 more), Mexico, Bahamas, USA
More At Sea OfferExclusive Solo Offer
INSIDE
$1,752
OCEANVIEW
$1,782
BALCONY
$1,874
SUITE
$1,981
From (per person) 1,752
View Trip
12 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Panama City to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 16 February 2026
Countries Visited: Panama, Colombia, Aruba, Saint Lucia (+4 more), Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
More At Sea OfferExclusive Solo Offer
INSIDE
$3,788
OCEANVIEW
$4,324
BALCONY
$5,822
SUITE
$6,206
From (per person) 3,788
View Trip
12 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Panama City to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 09 February 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
More At Sea Offer
INSIDE
$2,729
OCEANVIEW
$2,805
BALCONY
$5,299
SUITE
$5,374
From (per person) 2,729
View Trip
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