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Cruises from Rome to Barcelona

Are you looking for a cruise from Rome to Barcelona? May and September are the most popular months to cruise between Rome and Barcelona and there are 140 departures available from sixteen of the world's leading cruise lines.
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72 Cruises (140 Cruise Departures)
11 Day Grand Mediterranean with Princess
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Majestic Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Deal
INSIDE
$2,927
OCEANVIEW
-
BALCONY
$2,842
SUITE
$3,779
From (per person) 2,842
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+7 more), Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Dec 2024 to Sep 2026
Countries Visited: Italy, Monaco, France, Spain
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$5,143
SUITE
$6,232
Save (per person) 2,460
From (per person) 5,143
View Trip
9 Day Western Mediterranean Cruise: Italy, France & Spain with Azamara Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Pursuit
Departure: 09 October 2025
Countries Visited: Italy, France, Spain
INSIDE
$2,453
OCEANVIEW
$3,245
BALCONY
$3,998
SUITE
$6,275
From (per person) 2,453
View Trip
12 Day Grand Mediterranean with Princess
Cruise
 (2)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Deal
INSIDE
$3,509
OCEANVIEW
$4,122
BALCONY
$5,657
SUITE
$6,716
From (per person) 3,509
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2026 to Sep 2026
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$3,935
OCEANVIEW
$4,832
BALCONY
$5,614
SUITE
$7,079
From (per person) 3,935
View Trip
12 Day Grand Western Mediterranean with Princess
Cruise
 (2)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 29 July 2025
Countries Visited: Italy, Sicily, France, Gibraltar (+1 more), Spain
Exclusive Deal
INSIDE
$2,808
OCEANVIEW
$3,967
BALCONY
$4,076
SUITE
$5,145
From (per person) 2,808
View Trip
22 Day Western Mediterranean: Lisbon Overnight with Holland America
Cruise
 (2)

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 29 June 2025
Countries Visited: Italy, Sicily, Greece, Malta (+6 more), Tunisia, Sardinia, Spain, Morocco, Portugal, Gibraltar
Exclusive Deal
INSIDE
-
OCEANVIEW
$6,295
BALCONY
$8,225
SUITE
$10,453
From (per person) 6,295
View Trip
11 Day Mediterranean Melange with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 29 October 2025
Countries Visited: Italy, Sicily, Sardinia, Corsica (+3 more), Monaco, France, Spain
Bonus SavingsExclusive Deal
INSIDE
$3,690
OCEANVIEW
$4,255
BALCONY
$6,662
SUITE
$9,070
Save (per person) 2,220
From (per person) 3,690
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 16 April 2025
Countries Visited: Italy, Spain
Exclusive Deal
INSIDE
$429
OCEANVIEW
$507
BALCONY
$613
SUITE
$1,001
From (per person) 429
View Trip
8 Day Europe - Mediterranean with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Oct 2026
Countries Visited: Italy, Sicily, France, Spain
More At Sea Offer
INSIDE
$2,651
OCEANVIEW
-
BALCONY
$3,262
SUITE
$3,568
From (per person) 2,651
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departures: Jun 2026 to Jul 2026
Countries Visited: Italy, France, Gibraltar, Spain
Have It All Offer
INSIDE
$1,863
OCEANVIEW
$2,160
BALCONY
$2,606
SUITE
$4,091
From (per person) 1,863
View Trip
8 Day Mediterranean Cruise: Itlay, France & Spain with Azamara Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 07 November 2026
Countries Visited: Italy, France, Spain
INSIDE
$2,670
OCEANVIEW
$3,086
BALCONY
$3,967
SUITE
$5,482
From (per person) 2,670
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2025 to Aug 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$4,364
OCEANVIEW
$5,037
BALCONY
$6,542
SUITE
$6,938
From (per person) 4,364
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 06 September 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$4,791
OCEANVIEW
$6,494
BALCONY
$7,721
SUITE
$8,721
From (per person) 4,791
View Trip
10 Day Cities Of The Western Med Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 31 October 2024
Countries Visited: Italy, Monaco, France, Spain
INSIDE
-
OCEANVIEW
-
BALCONY
$6,553
SUITE
-
From (per person) 6,553
View Trip
12 Day Rivieras & Yacht Havens Voyage with Azamara Cruises
Cruise
 (2)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 26 August 2025
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$5,011
OCEANVIEW
$4,734
BALCONY
$6,417
SUITE
$7,278
From (per person) 4,734
View Trip
11 Day Autumnal Mediterranean with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Monaco, France, Spain
Bonus SavingsExclusive Deal
INSIDE
$3,973
OCEANVIEW
$4,405
BALCONY
$6,803
SUITE
$9,352
Save (per person) 2,237
From (per person) 3,973
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 29 August 2026
Countries Visited: Italy, Corsica, France, Gibraltar (+1 more), Spain
Have It All Offer
INSIDE
$1,913
OCEANVIEW
$2,210
BALCONY
$2,705
SUITE
$4,190
From (per person) 1,913
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Sep 2026 to Oct 2026
Countries Visited: Italy, Sicily, Greece, Montenegro (+2 more), Turkey, Spain
Exclusive Deal
INSIDE
$3,911
OCEANVIEW
$5,168
BALCONY
$6,337
SUITE
$7,792
From (per person) 3,911
View Trip
8 Day Western Mediterranean Cruise: Italy, France & Spain with Azamara Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 31 October 2026
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$2,600
OCEANVIEW
$3,006
BALCONY
$3,897
SUITE
$5,411
From (per person) 2,600
View Trip
31 Day Riviera, Mediterranean & Tyrrhenian Treasures with Seabourn
Cruise

31 Days (30 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 August 2025
Countries Visited: Italy, Malta, Tunisia, France (+5 more), Spain, Sardinia, Monaco, Sicily, Corsica
SAIL INTO SAVINGS
INSIDE
-
OCEANVIEW
-
BALCONY
$21,902
SUITE
-
From (per person) 21,902
View Trip
13 Day Greek Isles, Italy & Turkey with Celebrity Cruises
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 14 October 2024
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
$3,061
BALCONY
$3,721
SUITE
$7,809
Save (per person) 4,416
From (per person) 3,061
View Trip
8 Day Mediterranean Tapestry with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 15 November 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
$7,403
BALCONY
$8,799
SUITE
$12,056
Save (per person) 5,817
From (per person) 7,403
View Trip
9 Day Springtime Rivieras with Oceania Cruises
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 18 May 2025
Countries Visited: Italy, Corsica, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,337
SUITE
$8,505
Save (per person) 2,053
From (per person) 6,337
View Trip
10 Day Italian Riviera & France Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$1,860
OCEANVIEW
$2,329
BALCONY
$2,752
SUITE
$8,116
Save (per person) 3,242
From (per person) 1,860
View Trip
8 Day Rome To Barcelona with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 01 September 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$1,833
OCEANVIEW
$2,080
BALCONY
$2,377
SUITE
$4,506
From (per person) 1,833
View Trip
8 Day A Journey of Picturesque Piazzas & Soulful Souks with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
Anniversary Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$7,227
SUITE
$8,217
From (per person) 5,866
View Trip
10 Day Italy to France & Spain with Virgin Voyages
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 07 October 2025
Countries Visited: Italy, Sardinia, Corsica, France (+1 more), Spain
70% Off Second Sailor + Save
INSIDE
$2,508
OCEANVIEW
$2,863
BALCONY
$3,263
SUITE
$6,225
From (per person) 2,508
View Trip
22 Day Greece, Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 26 May 2025
Countries Visited: Italy, Greece, Montenegro, Croatia (+3 more), Malta, Corsica, Spain
Exclusive Deal
INSIDE
$5,412
OCEANVIEW
$5,699
BALCONY
-
SUITE
-
From (per person) 5,412
View Trip
10 Day Pesto, Paella & Paradise with Regent Seven Seas
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 17 April 2026
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,182
SUITE
$11,468
Save (per person) 5,828
From (per person) 9,182
View Trip
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