Home > Cruises > Central America Cruises > Panama > Cruises From Colon

Cruises From Colon

Choose from 19 unique cruises starting in Colon, and travelling to Cancun, Cartagena, Fort-de-France, Los Angeles and Puntarenas. December, January and March are the most popular months to join a cruise from Colon and you can select from 38 departures available from three leading cruise lines.
Filter Results
Departures
Show More...
Duration
2 Days
13 Days
End City
Ship Features
Operators
Price
$200pp
$14,160pp
Countries
Show More...
Filter Results
19 Cruises (38 Cruise Departures)
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Nov 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive DealExclusive Solo Offer
INSIDE
$1,343
OCEANVIEW
$1,404
BALCONY
$1,559
SUITE
$2,094
Save (per person) 756
From (per person) 1,343
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Dec 2025 to Feb 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive DealExclusive Solo Offer
INSIDE
$1,084
OCEANVIEW
$1,235
BALCONY
$1,520
SUITE
$2,368
Save (per person) 940
From (per person) 1,084
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Dec 2025 to Feb 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive DealExclusive Solo Offer
INSIDE
$1,159
OCEANVIEW
$1,303
BALCONY
$1,588
SUITE
$2,444
Save (per person) 807
From (per person) 1,159
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 06 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive DealExclusive Solo Offer
INSIDE
$1,325
OCEANVIEW
$1,441
BALCONY
$1,638
SUITE
$2,371
Save (per person) 695
From (per person) 1,325
View Trip
13 Day Panama, Colombia & Caribbean Islands with Ponant
Cruise

13 Days (12 Nights) Colon to Fort-de-France
Cruise Line: Ponant
Ship: Le Bellot
Departure: 15 March 2025
Countries Visited: Panama, Colombia, Bonaire, Saint Vincent (+3 more), Saint Lucia, Guadeloupe, Martinique
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$11,670
SUITE
$18,804
Save (per person) 220
From (per person) 11,670
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Bellot
Departures: Feb 2025 to Feb 2025
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$11,912
SUITE
$21,565
Save (per person) 268
From (per person) 11,912
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive DealExclusive Solo Offer
INSIDE
$1,325
OCEANVIEW
$1,419
BALCONY
$1,363
SUITE
$2,095
Save (per person) 749
From (per person) 1,325
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive DealExclusive Solo Offer
INSIDE
$1,740
OCEANVIEW
$1,890
BALCONY
$2,175
SUITE
$3,025
Save (per person) 885
From (per person) 1,740
View Trip
9 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

9 Days (8 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 12 December 2025
Countries Visited: Panama, Colombia, Bonaire, Aruba (+1 more), Curacao
Exclusive DealExclusive Solo Offer
INSIDE
$1,578
OCEANVIEW
$1,625
BALCONY
$1,849
SUITE
$2,452
Save (per person) 802
From (per person) 1,578
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,174
SUITE
$13,779
Save (per person) 156
From (per person) 8,174
View Trip
11 Day A Tropical Odyssey in Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Cancun
Cruise Line: Ponant
Ship: Le Champlain
Departure: 03 December 2025
Countries Visited: Panama, Costa Rica, Colombia, Honduras (+3 more), Guatemala, Belize, Mexico
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$10,328
SUITE
$15,904
Save (per person) 192
From (per person) 10,328
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 17 January 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive DealExclusive Solo Offer
INSIDE
$1,132
OCEANVIEW
$1,275
BALCONY
$1,560
SUITE
$2,416
Save (per person) 603
From (per person) 1,132
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America - with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Bellot
Departure: 06 January 2025
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$10,771
SUITE
$15,739
Save (per person) 209
From (per person) 10,771
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive DealExclusive Solo Offer
INSIDE
$1,167
OCEANVIEW
$1,311
BALCONY
$1,596
SUITE
$2,388
Save (per person) 796
From (per person) 1,167
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Nov 2025
Countries Visited: Panama, Colombia, Bonaire, Curacao
Exclusive DealExclusive Solo Offer
INSIDE
$1,335
OCEANVIEW
$1,410
BALCONY
$1,525
SUITE
$2,168
Save (per person) 703
From (per person) 1,335
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Colon to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 14 November 2025
Countries Visited: Panama, Costa Rica, Nicaragua, Guatemala (+2 more), Mexico, USA
Bonus SavingsExclusive Deal
INSIDE
$4,981
OCEANVIEW
$5,578
BALCONY
$8,127
SUITE
$11,414
Save (per person) 2,589
From (per person) 4,981
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive DealExclusive Solo Offer
INSIDE
$1,312
OCEANVIEW
$1,456
BALCONY
$1,365
SUITE
$2,480
Save (per person) 689
From (per person) 1,312
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Countries Visited: Panama, Colombia
Exclusive DealExclusive Solo Offer
INSIDE
$207
OCEANVIEW
$275
BALCONY
$326
SUITE
$475
Save (per person) 177
From (per person) 207
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$10,540
SUITE
$18,086
Save (per person) 200
From (per person) 10,540
View Trip
Results: 19 results

No Results found. Try changing your search filters.




Cruises found! Scroll up to view

South & Central America Cruises

Central America Cruises South America Cruises Mexico Cruises Galapagos Cruises Bermunda Cruises Bahamas Cruises Caribbean Cruises Amazon Cruises Patagonia Cruises Cape Horn Cruises Falkland Island Cruises Panama Cruises

Travel Styles

Luxury Cruises

Departure Months

January 2025 February 2025 March 2025 October 2025 November 2025 December 2025 January 2026 February 2026 March 2026 April 2026

Cities

Colon Panama City Santiago

Routes

Colon to Colon Panama City to Miami

Country Routes

Panama to USA USA to Panama

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

Central America Tours

All Central America Tours Belize Tours Costa Rica Tours Guatemala Tours Mexico Tours Panama Tours

© 2010-2024. Global Journeys. You're viewing our site in Australian dollars.

    

About Us | View Your Booking | Terms & Conditions | Site Map | We're Hiring!

Global Journeys Pty Ltd. Member of The Australian Travel Industry Association (AITA) & ATAS Travel Accredited (No. A11351).

Travel Industry Associations