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Royal Caribbean Cruises from Colon

Start your journey from Colon with 12 unique Royal Caribbean cruise itineraries to choose from. December, January and March are the most popular months to begin your cruise from Colon and Royal Caribbean have 29 trips departing this season.
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2 Days
9 Days
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$200pp
$2,785pp
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12 Cruises (29 Cruise Departures)
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Nov 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive DealExclusive Solo Offer
INSIDE
$1,343
OCEANVIEW
$1,404
BALCONY
$1,559
SUITE
$2,094
Save (per person) 756
From (per person) 1,343
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Dec 2025 to Feb 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive DealExclusive Solo Offer
INSIDE
$1,084
OCEANVIEW
$1,235
BALCONY
$1,520
SUITE
$2,368
Save (per person) 940
From (per person) 1,084
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Dec 2025 to Feb 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive DealExclusive Solo Offer
INSIDE
$1,159
OCEANVIEW
$1,303
BALCONY
$1,588
SUITE
$2,444
Save (per person) 807
From (per person) 1,159
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 06 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive DealExclusive Solo Offer
INSIDE
$1,325
OCEANVIEW
$1,441
BALCONY
$1,638
SUITE
$2,371
Save (per person) 695
From (per person) 1,325
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive DealExclusive Solo Offer
INSIDE
$1,325
OCEANVIEW
$1,419
BALCONY
$1,363
SUITE
$2,095
Save (per person) 749
From (per person) 1,325
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive DealExclusive Solo Offer
INSIDE
$1,740
OCEANVIEW
$1,890
BALCONY
$2,175
SUITE
$3,025
Save (per person) 885
From (per person) 1,740
View Trip
9 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

9 Days (8 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 12 December 2025
Countries Visited: Panama, Colombia, Bonaire, Aruba (+1 more), Curacao
Exclusive DealExclusive Solo Offer
INSIDE
$1,578
OCEANVIEW
$1,625
BALCONY
$1,849
SUITE
$2,452
Save (per person) 802
From (per person) 1,578
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 17 January 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive DealExclusive Solo Offer
INSIDE
$1,132
OCEANVIEW
$1,275
BALCONY
$1,560
SUITE
$2,416
Save (per person) 603
From (per person) 1,132
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive DealExclusive Solo Offer
INSIDE
$1,167
OCEANVIEW
$1,311
BALCONY
$1,596
SUITE
$2,388
Save (per person) 796
From (per person) 1,167
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Nov 2025
Countries Visited: Panama, Colombia, Bonaire, Curacao
Exclusive DealExclusive Solo Offer
INSIDE
$1,335
OCEANVIEW
$1,410
BALCONY
$1,525
SUITE
$2,168
Save (per person) 703
From (per person) 1,335
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive DealExclusive Solo Offer
INSIDE
$1,312
OCEANVIEW
$1,456
BALCONY
$1,365
SUITE
$2,480
Save (per person) 689
From (per person) 1,312
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Countries Visited: Panama, Colombia
Exclusive DealExclusive Solo Offer
INSIDE
$207
OCEANVIEW
$275
BALCONY
$326
SUITE
$475
Save (per person) 177
From (per person) 207
View Trip
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